Virus dynamics mathematical principles of immunology and virology

SAL3 off-campus storage. N68 Available. More options. Find it at other libraries via WorldCat Limited preview. Martin A. Contributor May, Robert M.

Robert McCredie , Bibliography Includes bibliographical references p. Contents Preface 1. Introduction: Viruses, immunity, equations 2. HIV 3. The basic model of virus dynamics 4. Anti-viral drug therapy 5. Dynamics of hepatitis B virus 6. Dynamics of immune responses 7. How fast do immune responses eliminate infected cells? What is a quasispecies 9.

The frequency of resistant mutant virus before anti-viral therapy Emergence of drug resistance We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus HIV. Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS.

Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses.

The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.

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